Publications

  • Zhang P, Rumschitzki D, Edwards RH. High-speed imaging reveals the bimodal nature of dense core vesicle exocytosis. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2214897120. doi: 10.1073/pnas.2214897120. Epub 2022 Dec 27. PMID: 36574702. View in: Pubmed
  • Li F, Eriksen J, Finer-Moore J, Stroud RM, Edwards RH. Diversity of function and mechanism in a family of organic anion transporters. Curr Opin Struct Biol. 2022 Aug;75:102399. doi: 10.1016/j.sbi.2022.102399. Epub 2022 Jun 2. PMID: 35660266. View in: Pubmed
  • Xu H, Chang F, Jain S, Heller BA, Han X, Liu Y, Edwards RH. SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3. J Cell Biol. 2022 May 2;221(5):e202106083. doi: 10.1083/jcb.202106083. Epub 2022 Apr 15. PMID: 35426896; PMCID: PMC9016777. View in: Pubmed
  • Eriksen J, Li F, Stroud RM, Edwards RH. Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody. Biochemistry. 2021 Aug 17;60(32):2463-2470. doi: 10.1021/acs.biochem.1c00375. Epub 2021 Jul 28. PMID: 34319067; PMCID: PMC8823281. View in: Pubmed
  • Runwal G, Edwards RH. The Membrane Interactions of Synuclein: Physiology and Pathology. Annu Rev Pathol. 2021 Jan 24;16:465-485. doi: 10.1146/annurev-pathol-031920-092547. PMID: 33497259. View in: PubMed
  • Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM. Ion transport and regulation in a synaptic vesicle glutamate transporter. Science. 2020 May 22;368(6493):893-897. doi: 10.1126/science.aba9202. PMID: 32439795. View in: PubMed
  • Eriksen J, Li F, Edwards RH. The mechanism and regulation of vesicular glutamate transport: Coordination with the synaptic vesicle cycle. Biochim Biophys Acta Biomembr. 2020 Mar 05; 183259. PMID: 32147354. View in: PubMed 
  • Leano JB, Batarni S, Eriksen J, Juge N, Pak JE, Kimura-Someya T, Robles-Colmenares Y, Moriyama Y, Stroud RM, Edwards RH. Structures suggest a mechanism for energy coupling by a family of organic anion transporters. PLoS Biol. 2019 05; 17(5):e3000260. PMID: 31083648.View in: PubMed 
  • Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH. Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties. Neuron. 2019 May 22; 102(4):786-800.e5. PMID: 31003725.View in: PubMed 
  • Chang R, Eriksen J, Edwards RH. The dual role of chloride in synaptic vesicle glutamate transport. Elife. 2018 07 24; 7. PMID: 30040066.View in: PubMed 
  • Ullman JC, Yang J, Sullivan M, Bendor J, Levy J, Pham E, Silm K, Seifikar H, Sohal VS, Nicoll RA, Edwards RH. A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. Nat Commun. 2018 01 23; 9(1):330. PMID: 29362376.View in: PubMed 
  • Pathak D, Berthet A, Bendor JT, Yu K, Sellnow RC, Orr AL, Nguyen MK, Edwards RH, Manfredsson FP, Nakamura K. Loss of a-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. eNeuro. 2017 Mar-Apr; 4(2). PMID: 28462393.View in: PubMed 
  • Logan T, Bendor J, Toupin C, Thorn K, Edwards RH. a-Synuclein promotes dilation of the exocytotic fusion pore. Nat Neurosci. 2017 May; 20(5):681-689. PMID: 28288128.View in: PubMed 
  • Maas JW, Yang J, Edwards RH. Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons. Front Synaptic Neurosci. 2017; 9:5. PMID: 28280464.View in: PubMed 
  • Silm K, Edwards RH. One Cycle Fuels Another: The Energetics of Neurotransmitter Release. Neuron. 2017 Feb 08; 93(3):470-472. PMID: 28182901.View in: PubMed 
  • Sheng N, Yang J, Silm K, Edwards RH, Nicoll RA. A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons. Neuropharmacology. 2017 03 15; 115:4-9. PMID: 27567940.View in: PubMed 
  • Mende M, Fletcher EV, Belluardo JL, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI, Francesconi A, Edwards RH, Milner TA, Rajadhyaksha AM, van Roessel PJ, Mentis GZ, Kaltschmidt JA. Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord. Neuron. 2016 06 15; 90(6):1189-1202. PMID: 27263971.View in: PubMed 
  • Eriksen J, Chang R, McGregor M, Silm K, Suzuki T, Edwards RH. Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism. Neuron. 2016 05 18; 90(4):768-80. PMID: 27133463.View in: PubMed 
  • Pathak D, Shields LY, Mendelsohn BA, Haddad D, Lin W, Gerencser AA, Kim H, Brand MD, Edwards RH, Nakamura K. The role of mitochondrially derived ATP in synaptic vesicle recycling. J Biol Chem. 2015 Sep 11; 290(37):22325-36. PMID: 26126824.View in: PubMed 
  • Edwards RH. Mobile binding sites regulate glutamate clearance. Nat Neurosci. 2015 Feb; 18(2):166-8. PMID: 25622571.View in: PubMed 
  • Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17. PMID: 25339743.View in: PubMed 
  • Incontro S, Asensio CS, Edwards RH, Nicoll RA. Efficient, complete deletion of synaptic proteins using CRISPR. Neuron. 2014 Sep 03; 83(5):1051-7. PMID: 25155957.View in: PubMed 
  • Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH. Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25; 27(4):425-37. PMID: 24210660.View in: PubMed 
  • Sirkis DW, Edwards RH, Asensio CS. Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3. PLoS Genet. 2013; 9(9):e1003812. PMID: 24086151.View in: PubMed 
  • Bendor JT, Logan TP, Edwards RH. The function of a-synuclein. Neuron. 2013 Sep 18; 79(6):1044-66. PMID: 24050397.View in: PubMed 
  • Foss SM, Li H, Santos MS, Edwards RH, Voglmaier SM. Multiple dileucine-like motifs direct VGLUT1 trafficking. J Neurosci. 2013 Jun 26; 33(26):10647-60. PMID: 23804088.View in: PubMed 
  • Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci. 2012 Oct 24; 32(43):15076-85. PMID: 23100428.View in: PubMed 
  • Akil O, Seal RP, Burke K, Wang C, Alemi A, During M, Edwards RH, Lustig LR. Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy. Neuron. 2012 Jul 26; 75(2):283-93. PMID: 22841313.View in: PubMed 
  • Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012 Jul 03; 16(1):113-21. PMID: 22768843.View in: PubMed 
  • Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92. PMID: 22483106.View in: PubMed 
  • Blakely RD, Edwards RH. Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harb Perspect Biol. 2012 Feb 01; 4(2). PMID: 22199021.View in: PubMed 
  • Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Ptácek LJ. Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. J Clin Invest. 2012 Feb; 122(2):507-18. PMID: 22214848.View in: PubMed 
  • Hnasko TS, Edwards RH. Neurotransmitter corelease: mechanism and physiological role. Annu Rev Physiol. 2012; 74:225-43. PMID: 22054239.View in: PubMed 
  • Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nat Neurosci. 2011 Aug 28; 14(10):1285-92. PMID: 21874016.View in: PubMed 
  • Hua Z, Leal-Ortiz S, Foss SM, Waites CL, Garner CC, Voglmaier SM, Edwards RH. v-SNARE composition distinguishes synaptic vesicle pools. Neuron. 2011 Aug 11; 71(3):474-87. PMID: 21835344.View in: PubMed 
  • Koch SM, Dela Cruz CG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron. 2011 Jul 28; 71(2):235-42. PMID: 21791283.View in: PubMed 
  • Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem. 2011 Jun 10; 286(23):20710-26. PMID: 21489994.View in: PubMed 
  • Asensio CS, Sirkis DW, Edwards RH. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010 Dec 13; 191(6):1173-87. PMID: 21149569.View in: PubMed 
  • Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll RA, Moriyama Y. Metabolic control of vesicular glutamate transport and release. Neuron. 2010 Oct 06; 68(1):99-112. PMID: 20920794.View in: PubMed 
  • Onoa B, Li H, Gagnon-Bartsch JA, Elias LA, Edwards RH. Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways. J Neurosci. 2010 Jun 09; 30(23):7917-27. PMID: 20534840.View in: PubMed 
  • Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron. 2010 Mar 11; 65(5):643-56. PMID: 20223200.View in: PubMed 
  • Noh J, Seal RP, Garver JA, Edwards RH, Kandler K. Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map. Nat Neurosci. 2010 Feb; 13(2):232-8. PMID: 20081852.View in: PubMed 
  • Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron. 2010 Jan 14; 65(1):66-79. PMID: 20152114.View in: PubMed 
  • Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature. 2009 Dec 03; 462(7273):651-5. PMID: 19915548.View in: PubMed 
  • Blankenship AG, Ford KJ, Johnson J, Seal RP, Edwards RH, Copenhagen DR, Feller MB. Synaptic and extrasynaptic factors governing glutamatergic retinal waves. Neuron. 2009 Apr 30; 62(2):230-41. PMID: 19409268.View in: PubMed 
  • Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, Sulzer D. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. 2009 Apr 30; 62(2):218-29. PMID: 19409267.View in: PubMed 
  • Edwards R. What the neuron tells glia. Neuron. 2009 Mar 26; 61(6):811-2. PMID: 19323989.View in: PubMed 
  • Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. J Neurosci. 2008 Nov 19; 28(47):12305-17. PMID: 19020024.View in: PubMed 
  • Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH. Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron. 2008 Jan 24; 57(2):263-75. PMID: 18215623.View in: PubMed 
  • Chaudhry FA, Boulland JL, Jenstad M, Bredahl MK, Edwards RH. Pharmacology of neurotransmitter transport into secretory vesicles. Handb Exp Pharmacol. 2008; (184):77-106. PMID: 18064412.View in: PubMed 
  • Chaudhry FA, Edwards RH, Fonnum F. Vesicular neurotransmitter transporters as targets for endogenous and exogenous toxic substances. Annu Rev Pharmacol Toxicol. 2008; 48:277-301. PMID: 17883368.View in: PubMed 
  • Edwards RH. The neurotransmitter cycle and quantal size. Neuron. 2007 Sep 20; 55(6):835-58. PMID: 17880890.View in: PubMed 
  • Nakamura K, Edwards RH. Physiology versus pathology in Parkinson’s disease. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):11867-8. PMID: 17623781.View in: PubMed 
  • Johnson J, Fremeau RT, Duncan JL, Rentería RC, Yang H, Hua Z, Liu X, LaVail MM, Edwards RH, Copenhagen DR. Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci. 2007 Jul 04; 27(27):7245-55. PMID: 17611277.View in: PubMed 
  • Voglmaier SM, Edwards RH. Do different endocytic pathways make different synaptic vesicles? Curr Opin Neurobiol. 2007 Jun; 17(3):374-80. PMID: 17449236.View in: PubMed 
  • Hnasko TS, Edwards RH. Synaptic vesicles: half full or half empty? Neuron. 2006 Sep 07; 51(5):523-4. PMID: 16950150.View in: PubMed 
  • Voglmaier SM, Kam K, Yang H, Fortin DL, Hua Z, Nicoll RA, Edwards RH. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron. 2006 Jul 06; 51(1):71-84. PMID: 16815333.View in: PubMed 
  • Seal RP, Edwards RH. Functional implications of neurotransmitter co-release: glutamate and GABA share the load. Curr Opin Pharmacol. 2006 Feb; 6(1):114-9. PMID: 16359920.View in: PubMed 
  • Li H, Waites CL, Staal RG, Dobryy Y, Park J, Sulzer DL, Edwards RH. Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron. 2005 Nov 23; 48(4):619-33. PMID: 16301178.View in: PubMed 
  • Fortin DL, Nemani VM, Voglmaier SM, Anthony MD, Ryan TA, Edwards RH. Neural activity controls the synaptic accumulation of alpha-synuclein. J Neurosci. 2005 Nov 23; 25(47):10913-21. PMID: 16306404.View in: PubMed 
  • Kubo S, Nemani VM, Chalkley RJ, Anthony MD, Hattori N, Mizuno Y, Edwards RH, Fortin DL. A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem. 2005 Sep 09; 280(36):31664-72. PMID: 16020543.View in: PubMed 
  • Sulzer D, Edwards RH. Antidepressants and the monoamine masquerade. Neuron. 2005 Apr 07; 46(1):1-2. PMID: 15820686.View in: PubMed 
  • Boulland JL, Qureshi T, Seal RP, Rafiki A, Gundersen V, Bergersen LH, Fremeau RT, Edwards RH, Storm-Mathisen J, Chaudhry FA. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. J Comp Neurol. 2004 Dec 13; 480(3):264-80. PMID: 15515175.View in: PubMed 
  • Johnson J, Sherry DM, Liu X, Fremeau RT, Seal RP, Edwards RH, Copenhagen DR. Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina. J Comp Neurol. 2004 Sep 27; 477(4):386-98. PMID: 15329888.View in: PubMed 
  • Burman J, Tran CH, Glatt C, Freimer NB, Edwards RH. The effect of rare human sequence variants on the function of vesicular monoamine transporter 2. Pharmacogenetics. 2004 Sep; 14(9):587-94. PMID: 15475732.View in: PubMed 
  • Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH. Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci. 2004 Jul 28; 24(30):6715-23. PMID: 15282274.View in: PubMed 
  • Fremeau RT, Kam K, Qureshi T, Johnson J, Copenhagen DR, Storm-Mathisen J, Chaudhry FA, Nicoll RA, Edwards RH. Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science. 2004 Jun 18; 304(5678):1815-9. PMID: 15118123.View in: PubMed 
  • Fremeau RT, Voglmaier S, Seal RP, Edwards RH. VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci. 2004 Feb; 27(2):98-103. PMID: 15102489.View in: PubMed 
  • Wreden CC, Johnson J, Tran C, Seal RP, Copenhagen DR, Reimer RJ, Edwards RH. The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons. J Neurosci. 2003 Feb 15; 23(4):1265-75. PMID: 12598615.View in: PubMed 
  • Johnson J, Tian N, Caywood MS, Reimer RJ, Edwards RH, Copenhagen DR. Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate. J Neurosci. 2003 Jan 15; 23(2):518-29. PMID: 12533612.View in: PubMed 
  • Fremeau RT, Burman J, Qureshi T, Tran CH, Proctor J, Johnson J, Zhang H, Sulzer D, Copenhagen DR, Storm-Mathisen J, Reimer RJ, Chaudhry FA, Edwards RH. The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14488-93. PMID: 12388773.View in: PubMed 
  • Chaudhry FA, Reimer RJ, Edwards RH. The glutamine commute: take the N line and transfer to the A. J Cell Biol. 2002 Apr 29; 157(3):349-55. PMID: 11980913.View in: PubMed 
  • Chaudhry FA, Schmitz D, Reimer RJ, Larsson P, Gray AT, Nicoll R, Kavanaugh M, Edwards RH. Glutamine uptake by neurons: interaction of protons with system a transporters. J Neurosci. 2002 Jan 01; 22(1):62-72. PMID: 11756489.View in: PubMed